This is the first time I've perused this thread, so if this has been covered before, oh well 8)
with regards to the use of moleskin, Paracowboy was absolutely correct in that the adhesive on moleskin is not up to the task.
One thing that is up to the task, except under extreme conditions (hours of immersion, incredibly poor fitting boots, etc), is Tinc Benz (friar's balsam) such as this
http://www.mec.ca/Products/product_detail.jsp?PRODUCT%3C%3Eprd_id=845524441931941&FOLDER%3C%3Efolder_id=2534374302695977&bmUID=1176096128250
used as an adhesive to hold either the moleskin in place, or the Spenco adhesive knit over top of Second Skin (tm), such as this:
http://www.mec.ca/Products/product_detail.jsp?PRODUCT%3C%3Eprd_id=845524442620247&FOLDER%3C%3Efolder_id=2534374302695977&bmUID=1176096226153
You will hear old soldiers talk about the "friar's balsam treatment". I'm not even to tell you what it is, because someone will get an idea and try it. Suffice to say, do not get tinc benz in an open cut. DO NOT GET TINC BENZ IN AN OPEN CUT.
If you're going to "glue" down the bandage, ensure you round the edges so they don't roll on you and worsen the problem, apply the glue to both the dressing and the skin around the blister, give it a second to get tacky, and apply. Trim the edges again as necessary.
These products have taken trips from miserable to tolerable, and from tolerable to wonderful, especially in new hiking boots, plastic mountaineering boots, and ski touring boots.
PMT